منابع مشابه
BRAIN MAPPING IN NEUROSURGERY
Background and Aim: Brain mapping is a study of the anatomy and function of the CNS (central nervous system). Brain mapping has many techniques and these techniques are permanently changing and updating. From the beginning, brain mapping was invasive and for brain mapping, electrical stimulation of the exposed brain was needed. However, nowadays brain mapping does not require electrical stimula...
متن کاملHuman apoE isoforms differentially regulate brain amyloid-β peptide clearance.
The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease (AD). The APOE ε4 allele markedly increases AD risk and decreases age of onset, likely through its strong effect on the accumulation of amyloid-β (Aβ) peptide. In contrast, the APOE ε2 allele appears to decrease AD risk. Most rare, early-onset forms of familial AD are caused b...
متن کاملOptimized protocol for amyloid-β extraction from the brain.
Brain levels of amyloid-β (Aβ) are frequently assessed in transgenic mice models of Alzheimer's disease. The procedure involves tissue sample homogenization using different buffers in a sequential process. No attempt has been made to assess if these procedures are able to extract the total amount of Aβ present in the samples. Here we present data suggesting that standard protocols can lead to a...
متن کاملMonitoring of β-amyloid dynamics after human traumatic brain injury.
Epidemiological evidence links severe or repeated traumatic brain injury (TBI) to the development of Alzheimer's disease (AD). Accumulation of amyloid precursor protein (APP) occurs with high frequency after TBI, particularly in injured axons, and APP may be cleaved to amyloid-β (Aβ) peptides playing key pathophysiological roles in AD. We used cerebral microdialysis (MD) to test the hypothesis ...
متن کاملAmyloid β -peptide Promotes Permeability Transition Pore in Brain Mitochondria
In this work the effect of the neurotoxic amino acid sequence, Aβ25–35 , on brain mitochondrial permeability transition pore (PTP) was studied. For the purpose, the mitochondrial transmembrane potential (∆Ψm), mitochondrial respiration and the calcium fluxes were examined. It was observed that Aβ25–35, in the presence of Ca, decreased the ∆Ψm, the capacity of brain mitochondria to accumulate ca...
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ژورنال
عنوان ژورنال: Current Opinion in Neurology
سال: 2009
ISSN: 1350-7540
DOI: 10.1097/wco.0b013e32832d93c7